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FENO was measured with a portable electrochemical analyzer and forced spirometry was performed according to American Thoracic Society/European Respiratory Society. <a href="http://www.selleckchem.com/products/FK-506-(Tacrolimus).html">buy FK506</a> The CAN questionnaire was completed by the parents (aged <9 years old) or by the children (��9 years old). The strength of the association among FEV1, FENO, and CAN questionnaire was studied using Spearman's rho, and the degree of agreement for asthma control among FEV1, FENO, and CAN questionnaire, with classification of these variables according to values of normality, was studied using Pearson's ��2 test and Cohen's kappa (KC). We studied 268 children, mean age 9.7?��?2.1 years. Significant correlations were found between FENO and CAN (r?=?0.2), between FEV1 and CAN (r?=??0.3), and between FENO and FEV1 (r?=??0.12). On classifying the variables according to values of normality, no agreement was found to establish <a href="https://en.wikipedia.org/wiki/Calpain">Calpain</a> the degree of asthma control between FENO and CAN (KC?=?0.18, ��2 Pearson?=?9.63); between FEV1 and CAN (KC?=?0.29, ��2?=?38.5); or between FENO and FEV1 (KC?=?0.07, ��2?=?4.9). The association among the three measurement instruments used to assess asthma control (FEV1, FENO, and CAN) was weak. These are instruments that quantify variables that influence asthma in different ways, in this sense, none can be used instead of another in asthma management although they are complementary. Pediatr Pulmonol. 2010; 45:434�C439. ? 2010 Wiley-Liss, Inc. ""With advances in cardiac care, patients with congenital heart disease, including single ventricle (SV) physiology, now survive into adulthood. These patients often suffer from congestive heart failure (CHF) with overexpression of serum biomarkers. Strain and strain rate (SR) may better describe the myocardial mechanics of a failing SV. Our objective was to determine the correlation between strain/SR and biomarkers in adult patients with SV and CHF. Adult patients (age ��8 years) with a SV were enrolled. Strain/SR in a 16-segment model of a SV was measured using 2D speckle echocardiography. Serum levels of interleukin 6, interleukin <a href="http://www.selleckchem.com/products/Belinostat.html">selleck screening library</a> 8, matrix metalloproteinase 9, procollagen I C-terminal peptide (PCIP), cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), pro-B-type natriuretic peptide, nitrotryrosine, tissue growth factor beta (TGF-��), tumor necrosis factor alpha, vascular endothelial growth factor, and creatinine (Cr) were measured. Patients underwent a complete 6 Minute Walk Test (MWT). Pearson correlation coefficient was used. P <.05 was considered significant. Ten patients with SV (LV = 7, RV = 3) were enrolled. Mean age was 35.5 years (25�C42 years). Mean single ventricular ejection fraction (SVEF) was 47%. ICTP correlated with the basal, mid, and apical anterolateral SR, as well as apical anterior and inferior SR. PCIP correlated with mid anterolateral, basal anteroseptal, and mid inferolateral SR.
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